Award Number: W81XWH-10-1-0791 TITLE: Improving Joint Function Using Photochemical Hydrogels for Articular Surface Repair PRINCIPAL INVESTIGATOR:

s presented: Griffin D, Meppelink AM, Randolph MA, Cohen I, Bonassar LJ. Detection and Characterization of Local Interfacial Mechanics in a Cartilage Defect Repair Model. Poster presentation (#0343 ) at the annual meeting of the Orthopaedic Research Society, Las Vegas, NV, March 28-31, 2015. B.V. Sridhar, J.L. Brock, J.S. Silver, M.A. Randolph, J.L. Leight, K.S. Anseth. Development of a cellularly degradable PEG hydrogel to promote articular cartilage matrix deposition. 249 American Chemical Society National Meeting and Exposition, Denver, CO, March 22-26, 2015. Published manuscripts: Sridhar BV, Doyle NR, Randolph MA, Anseth KS. Covalently tethered TGF-β1 with encapsulated chondrocytes in a PEG hydrogel system enhances extracellular matrix production. J Biomed Mater Res A. 2014 Dec;102(12):4464-72. doi:10.1002/jbm.a.35115. Epub 2014 Feb 26. PubMed PMID: 24616326; PubMed Central PMCID: PMC4145048. Sridhar BV, Brock JL, Silver JS, Leight JL, Randolph MA, Anseth KS. Development of a cellularly degradable PEG hydrogel to promote articularcartilage extracellular matrix deposition. Adv Healthc Mater. 2015 Apr 2;4(5):702-13. doi: 10.1002/adhm.201400695. Epub 2015 Jan 21. PubMed PMID:25607633; PubMed Central PMCID: PMC4487633. Sridhar BV, Dailing EA, Brock JL, Stansbury JW, Randolph MA, Anseth KS. A Biosynthetic Scaffold that Facilitates Chondrocyte-Mediated Degradation and Promotes Articular Cartilage Extracellular Matrix Deposition. Regen. Eng. Transl. Med. DOI 10.1007/s40883-015-0002-3 Manuscript drafted for submission to Tissue Engineering: Meppelink AM, Zhao X, Griffin D, Erali R, Bonassar LJ , Redmond RW, Randolph MA. Articular Cartilage Matrix Formation using Dynamic Self-Regenerating Cartilage and Photochemical Hydrogels.